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Mac and Cheese Meatloaf Casserole

Mac and Cheese Meatloaf Casserole: How to Make the Best Comfort Food


  • Author: Emma

Description

A delicious combination of homemade mac and cheese layered with savory meatloaf, creating the ultimate comfort food casserole.


Ingredients

Scale

For the Meatloaf Layer:

  • 2 pounds lean ground beef (90/10 recommended for flavor balance)
  • 1 cup breadcrumbs (panko provides the best texture)
  • 2 large eggs, lightly beaten
  • 1 medium onion, finely diced
  • 1 red bell pepper, finely chopped
  • 3 cloves garlic, minced
  • 2 tablespoons Worcestershire sauce
  • 1 tablespoon Dijon mustard
  • 1 teaspoon dried oregano
  • 1 teaspoon dried thyme
  • 1 teaspoon smoked paprika
  • 1/2 teaspoon freshly ground black pepper
  • 1 teaspoon salt

For the Mac and Cheese Layer:

  • 16 ounces elbow macaroni
  • 4 tablespoons unsalted butter
  • 1/4 cup all-purpose flour
  • 3 cups whole milk (substitute with 2% for lighter option)
  • 1 cup chicken broth
  • 3 cups shredded sharp cheddar cheese (about 12 ounces)
  • 1 cup shredded Gruyère or Monterey Jack cheese
  • 1/2 teaspoon garlic powder
  • 1/4 teaspoon cayenne pepper (optional)
  • Salt and pepper to taste

For the Topping:

  • 1 cup panko breadcrumbs
  • 2 tablespoons melted butter
  • 1/2 cup shredded cheddar cheese
  • 1 tablespoon chopped fresh parsley

Instructions

Step 1: Prepare Your Oven and Baking Dish

Step 2: Create the Meatloaf Mixture

Step 3: Form the Meatloaf Base

Step 4: Pre-Bake the Meatloaf Layer

Step 5: Prepare the Pasta

Step 6: Create the Cheese Sauce

Step 7: Add the Cheese

Step 8: Combine Pasta and Cheese Sauce

Step 9: Layer and Top the Casserole

Step 10: Bake to Perfection

Notes

  • You can prepare components up to a day ahead and store separately in the refrigerator.
  • Add 10-15 minutes to baking time if assembling from cold ingredients.
  • The casserole is done when top is golden brown, edges are bubbling, and meatloaf reaches 160°F.
  • For the creamiest mac and cheese, use sharp cheddar for flavor combined with Gruyère, Monterey Jack, or fontina for meltability.
  • To make gluten-free, use gluten-free pasta, breadcrumbs, and check Worcestershire sauce.
  • To prevent grainy cheese sauce, remove white sauce from heat before adding cheese.
  • Breadcrumbs can be substituted with crushed crackers, quick oats, or cooked quinoa.
  • Category: Main Dish
  • Method: Baking
  • Cuisine: American

Keywords: mac and cheese meatloaf casserole, comfort food, casserole recipe, main dish